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  • Title: Effect of previous argon laser trabeculoplasty on the ocular hypotensive action of latanoprost.
    Author: Arranz-Marquez E, Teus MA.
    Journal: Graefes Arch Clin Exp Ophthalmol; 2006 Sep; 244(9):1073-6. PubMed ID: 16416130.
    Abstract:
    PURPOSE: To study the effect of previous argon laser trabeculoplasty (ALT) on the hypotensive activity of latanoprost in primary open-angle glaucoma (POAG). METHODS: This was a prospective, observer-masked study. We measured the intraocular pressure (IOP) before and after 3 months of monotherapy with latanoprost in 43 eyes that had undergone a previous ALT, and in a control group (not treated with ALT) of 43 IOP-matched eyes with POAG. RESULTS: Latanoprost induced a 17.4+/-16.6% IOP decrease in the study group (ALT-treated eyes) and a 25.8+/-17.2% IOP reduction in the control eyes (P=0.02, unpaired Student's t-test). CONCLUSIONS: Latanoprost is less effective in ALT-treated eyes than in eyes with POAG not treated with ALT.
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