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  • Title: Real-time sizing of nanoparticles in microfluidic channels using confocal correlation spectroscopy.
    Author: Kuyper CL, Budzinski KL, Lorenz RM, Chiu DT.
    Journal: J Am Chem Soc; 2006 Jan 25; 128(3):730-1. PubMed ID: 16417357.
    Abstract:
    This Communication reports real-time sizing of nanoparticles in microfluidic systems using confocal correlation spectroscopy (CCS). CCS can be used to measure the size of both fluorescent and nonfluorescent particles at low concentrations (<nanomolar) and in small volumes (<femtoliters). With advances in nonfluorescent modes of single-particle and single-molecule detection, we anticipate CCS will find broad use in the real-time measurements of nanoparticles and macromolecules.
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