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  • Title: Citalopram serum and milk levels in mother and infant during lactation.
    Author: Franssen EJ, Meijs V, Ettaher F, Valerio PG, Keessen M, Lameijer W.
    Journal: Ther Drug Monit; 2006 Feb; 28(1):2-4. PubMed ID: 16418683.
    Abstract:
    We present a case of intensified therapeutic drug monitoring (TDM) of citalopram in mother and newborn infant after clinically observed selective serotonin reuptake inhibitor (SSRI)-associated symptoms 2 weeks until 2 months after delivery. The SSRI-associated symptoms observed in the infant (up to 3 weeks after delivery) were irregular breathing, sleep disorders, hypotonia, and hypertonia. We conclude that the SSRI-associated symptoms in the infant represent citalopram withdrawal effects rather than side effects caused by breastfeeding. This case illustrates the importance of a flexible TDM program and a multidisciplinary approach in a hospital setting to deal with cases of drug-associated adverse effects, such as SSRI withdrawal effects.
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