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  • Title: Identification of GATA-1 and NF-E2 binding sites in the flanking regions of the human alpha-globin genes.
    Author: Gourdon G, Morlé F, Roche J, Tourneur N, Joulain V, Godet J.
    Journal: Acta Haematol; 1992; 87(3):136-44. PubMed ID: 1642094.
    Abstract:
    Some of the elements involved in the erythroid-specific transcriptional regulation of the human gamma- and beta-globin genes and located inside or in the immediate proximity of these genes have been identified as sequences which bind erythroid-specific factors. In the present study, we found two regions located within 1 kb in 5' to the alpha 2- and in 3' to the alpha 1-globin genes which contribute to the induction of human alpha-globin genes following erythroid differentiation in stable MEL transformants. By DNAse I footprinting and gel mobility shift assays, we identified several GATA-1 and one AP-1/NF-E2-binding sites located inside these regions. These results strengthen the idea that, like for all other globin genes, flanking regions contribute in vivo to the regulation of human alpha-globin gene expression.
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