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  • Title: Protective effect of donepezil on retinal ganglion cells in vitro and in vivo.
    Author: Miki A, Otori Y, Morimoto T, Okada M, Tano Y.
    Journal: Curr Eye Res; 2006 Jan; 31(1):69-77. PubMed ID: 16421021.
    Abstract:
    The neuroprotective effect of donepezil, an acetylcholinesterase inhibitor on retinal ganglion cells (RGCs), was examined. The survival of purified RGCs after exposure to glutamate with or without donepezil (10(- 7) M to 10(- 5) M) was measured after 3 days in culture. In vivo, the neuroprotective effect of donepezil was examined by quantifying the number of viable RGCs 7 days after axotomy in adult rats. In vitro, donepezil dose-dependently reduced RGC death caused by glutamate toxicity. Oral administration of donepezil (10 mg kg(-1) day(-1)) significantly reduced RGC death after axotomy. In conclusion, donepezil exerts a protective effect on RGCs both in vitro and in vivo.
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