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  • Title: Distribution and function of potassium channels in the electrosensory lateral line lobe of weakly electric apteronotid fish.
    Author: Mehaffey WH, Fernandez FR, Rashid AJ, Dunn RJ, Turner RW.
    Journal: J Comp Physiol A Neuroethol Sens Neural Behav Physiol; 2006 Jun; 192(6):637-48. PubMed ID: 16425062.
    Abstract:
    Potassium channels are one of the fundamental requirements for the generation of action potentials in the nervous system, and their characteristics shape the output of neurons in response to synaptic input. We review here the distribution and function of a high-threshold potassium channel (Kv3.3) in the electrosensory lateral line lobe of the weakly electric fish Apteronotus leptorhynchus, with particular focus on the pyramidal cells in this brain structure. These cells contain both high-threshold Kv3.3 channels, as well as low-threshold potassium channels of unknown molecular identity. Kv3.3 potassium channels regulate burst discharge in pyramidal cells and enable sustained high frequency firing through their ability to reduce an accumulation of low-threshold potassium current.
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