These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Low zinc and high copper levels in mothers of children with isolated cleft lip and palate].
    Author: Hozyasz KK, Ruszczyńska A, Bulska E.
    Journal: Wiad Lek; 2005; 58(7-8):382-5. PubMed ID: 16425788.
    Abstract:
    UNLABELLED: Changes in orofacial development have been reported in offspring of animals treated with copper injections or low zinc diet during pregnancy. The aim of our study was to determine serum levels of zinc and copper in mothers of children with non-syndromic orofacial clefts and in women who gave birth to healthy children. Ninety six healthy women participated in the study: 35 mothers of children with cleft lip and cleft palate (CLP), 30 mothers of children with cleft palate (CP) and 31 control mothers of healthy children. Serum zinc and copper concentrations were determined by the use of inductively coupled plasma-mass spectrometry (ICP-MS). RESULTS: Between CLP and controls there were significant differences in mean zinc levels (511 +/- 121 microg/L vs 572 +/- 76 microg/L, p = 0.012) and copper levels (991 +/- 388 microg/L vs 810 +/- 201 microg/L, p = 0.02). In CP mean serum zinc and copper levels were 540 +/- 130 microg/L and 846 +/- 291 microg/L. The ratio of serum zinc to copper levels was significantly lower in CLP comparing to CP and controls (0.57 +/- 0.19 vs 0.67 +/- 0.18 and 0.74 +/- 0.19, p = 0.003). CONCLUSION: Our results suggest that trace elements may play a role in facial clefting in humans.
    [Abstract] [Full Text] [Related] [New Search]