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  • Title: The influence of ebselen on the toxicity of cisplatin in LLC-PK1 cells.
    Author: Baldew GS, Boymans AP, Mol JG, Vermeulen NP.
    Journal: Biochem Pharmacol; 1992 Jul 22; 44(2):382-7. PubMed ID: 1642650.
    Abstract:
    LLC-PK1 cells have been used as an in vitro model to study the nephrotoxicity of the antitumor drug cisplatin. A concentration-dependent cytotoxicity of cisplatin, measured as lactate dehydrogenase leakage and amount of protein remaining attached to the culture plate, was observed. At a cisplatin concentration of 0.4 mM cell viability was reduced to 21% after 72 hr. Ebselen, a seleno-organic compound capable of forming selenol intermediates through reaction with thiols, was found to protect LLC-PK1 cells against cisplatin-induced toxicity at low concentrations (5-15 microM). The ebselen-induced protection against cisplatin toxicity in this in vitro test system apparently correlates well with a similar protection previously observed in vivo in mice and rats.
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