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  • Title: Deoxyribonuclease II from the Icelandic scallop (Chlamys islandica): isolation and partial characterization.
    Author: Øverbø K, Myrnes B.
    Journal: Comp Biochem Physiol B Biochem Mol Biol; 2006 Mar; 143(3):315-8. PubMed ID: 16426884.
    Abstract:
    A deoxyribonuclease (DNase) was isolated from viscera of the cold-adapted marine bivalve Icelandic scallop. The 42 kDa DNase was shown to be a single polypeptide which catalyses DNA hydrolysis in the absence of divalent cations. The isolated enzyme showed maximal activity at pH 6 and no activity above pH 7.2 against native DNA. The scallop DNase was slightly more susceptible to heat denaturation than porcine DNase II and makes double-strand breaks in circular DNA substrate as the porcine enzyme. The N-terminal sequence of the scallop DNase was shown to be closely similar to DNase II (EC 3.1.22.1) proteins from other organisms. The scallop DNase is in addition to plancitoxin I from A. planci, the only DNase II enzyme isolated from marine invertebrates.
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