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  • Title: Effects of tibolone on blood flow resistance and intima-media thickness of the carotid arteries: effect of time since menopause.
    Author: Somunkiran A, Yazici B, Demirci F, Erdogmus B, Ozdemir I.
    Journal: Climacteric; 2006 Feb; 9(1):59-65. PubMed ID: 16428126.
    Abstract:
    OBJECTIVE: The aim of this prospective study was to evaluate the effects of tibolone on carotid atherosclerosis in healthy postmenopausal women. METHODS: Twenty-five healthy postmenopausal women were included in the study. Patients received tibolone 2.5 mg daily for 6 months. Resistance indices of the common carotid artery (CCA), internal carotid artery (ICA), external carotid artery (ECA) and vertebral arteries, and intima-media thickness of the CCA were measured both at baseline and at the end of the study with ultrasonography. RESULTS: No significant differences were observed in the resistance indices of the CCA, ICA, ECA and vertebral arteries, as well as intima-media thickness of CCA at 6 months in comparison with baseline. Tibolone significantly improved the intima-media thickness of the CCA of women who were less than 18 months since menopause. CONCLUSION: Overall, these results demonstrate no significant effects of tibolone on either intima-media thickness or blood flow resistance in the carotid arteries in postmenopausal women. However, the results suggest that tibolone may have a positive effect on the vascular system if commenced within 18 months since menopause; this warrants further investigation.
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