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  • Title: [Rapid diagnosis of Chlamydia trachomatis using a DNA probe in a population with low risk of infection].
    Author: Rosales M, Domínguez V, Bonacho I, Vidal X.
    Journal: Enferm Infecc Microbiol Clin; 1992 Feb; 10(2):111-4. PubMed ID: 1643131.
    Abstract:
    BACKGROUND: To assess the efficacy of a newer diagnostic technique for Chlamydia trachomatis and its usefulness as screening method in populations at low-risk for Chlamydia trachomatis infection. METHODS: Open comparative trial between the EIA technique (Abbott Laboratories) and DNA gene probe (Gen Probe Diagnostic). A total of 1683 individuals (1630 women and 53 men) were screened with the two different techniques using samples obtained simultaneously. RESULTS: Among women, 66 give a positive result either by one or another technique. The prevalence was 4.04%. Sensitivity of DNA probe when compared with EIA assay was 64% and specificity was 98.9%. CONCLUSIONS: The DNA probe technique is faster than actual techniques and easy to do without major laboratory equipment. However, its price is high and its sensitivity poor in low-risk populations.
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