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  • Title: [Quantification of the levels of p24 antigen and antibodies in human immunodeficiency virus infection].
    Author: García F, Quirós E, Bernal MC, Alados JC, González MI, Maroto MC.
    Journal: Enferm Infecc Microbiol Clin; 1992 Feb; 10(2):75-8. PubMed ID: 1643142.
    Abstract:
    BACKGROUND: Quantification and clinical evaluation of p24 antigen and anti-HIV antibody levels. METHODS: Follow up of 13 HIV infected patients (53 sera) by determination of p24 antigen, total anti-HIV antibodies, anti-p24 and anti-env antibodies by ELISA and their semiquantitation. IgG and IgM class antibody determination by immunoblot techniques. RESULTS: The highest levels of p24 have been found in WR 1 and WR 6 stages. Commonly accepted serologic pattern has not been found in 100% of our cases. Western-blot is more sensitive for the detection of anti-p24 antibodies. CONCLUSIONS: p24 antigen appearance and a decrease in anti-p24 antibody level is related to a worse clinical prognosis. p24 antigen quantification is a usefull test for monitoring AZT therapy in patients suffering from AIDS.
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