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  • Title: Alternatives for measuring endogenous adrenocortical activity in asthmatics treated with inhaled corticosteroids.
    Author: Buyantseva LV, Chinchilli VM, Tulchinsky M, Bascom R, Martin RJ.
    Journal: Endocr Res; 2005; 31(4):245-58. PubMed ID: 16433245.
    Abstract:
    We compared a 12-hour, hourly integrated plasma cortisol profile in asthmatics treated with a corticosteroids with a variety of modified methods based on less frequent blood sampling. Excellent agreement with the reference was observed for sampling at 10 p.m. and 8 a.m. (correlation coefficient of 0.97; 95 % confidence interval 0.97, 0.98); at 9 p.m. and 7 a.m. (r = 0. 95; 0. 94, 0.96); at 11 p.m. and 7 a.m. (r = 0.94; 0.93, 0.95); every 2 hours (r = 0. 96; 0.96, 0.97); and every 3 hours (r = 0. 91, 0.91, 0.93). The two-sample alternatives (10 p.m/8 a.m. and 9 p.m/7 a.m.) are accurate, as well as more convenient, economical, and practical.
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