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  • Title: Anticancer activities of novel chalcone and bis-chalcone derivatives.
    Author: Modzelewska A, Pettit C, Achanta G, Davidson NE, Huang P, Khan SR.
    Journal: Bioorg Med Chem; 2006 May 15; 14(10):3491-5. PubMed ID: 16434201.
    Abstract:
    A series of novel chalcones and bis-chalcones containing boronic acid moieties has been synthesized and evaluated for antitumor activity against the human breast cancer MDA-MB-231 (estrogen receptor-negative) and MCF7 (estrogen receptor-positive) cell lines and against two normal breast epithelial cell lines, MCF-10A and MCF-12A. These molecules inhibited the growth of the human breast cancer cell lines at low micromolar to nanomolar concentrations, with five of them (1-4, 9) showing preferential inhibition of the human breast cancer cell lines. Furthermore, bis-chalcone 8 exhibited a more potent inhibition of colon cancer cells expressing wild-type p53 than of an isogenic cell line that was p53-null.
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