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  • Title: Dopamine receptors do not influence beta2-sympathomimetic-mediated inhibition of gastric acid secretion in the dog.
    Author: Gottrup F, Hovendal CP, Andersen D.
    Journal: Scand J Gastroenterol; 1981 Apr; 16(3):357-60. PubMed ID: 16435476.
    Abstract:
    The effect of dopamine blockade by haloperidol and metoclopramide on beta2-adrenergic-induced changes of acid secretion and pulse rate was studied in conscious gastric fistula dogs. Neither haloperidol (0.15 mg/kg and 0.60 mg/kg) nor metoclopramide (0.25 mg/kg and 1.0 mg/kg), given intravenously, had a significant influence on beta2-adrenergic-induced inhibition of gastric acid secretion or tachycardia. Dopamine blockade had no influence on pentagastrin-stimulated gastric acid secretion, but it increased pulse rate. It is concluded that dopamine receptors are not involved in the inhibiton of acid output or tachycardia induced by beta2-sympathomimetics, and dopamine is probably not a neurotransmitter for these effects.
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