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  • Title: [Factor VIII hyperactivity: an arterio-venous thrombogenic factor. Case report].
    Author: Bennani SL, Vaquette B, Pavin D, Boulmier D, Daubert JC, Mabo P.
    Journal: Arch Mal Coeur Vaiss; 2005 Dec; 98(12):1253-6. PubMed ID: 16435607.
    Abstract:
    Thrombosis is the principal mechanism in vascular pathology, whether cerebral, coronary or peripheral. During the initial stages of infarction, coagulation contributes to vascular occlusion, the haemostatic factors playing a determining role in the development of atherothrombotic lesions. An increase in a coagulation protein, besides any lowering of anticoagulation protein levels, is a risk factor for thrombosis. Among these pro-coagulant factors, the pro-thrombogenic action of factor VIII has without doubt been studied the least. We report the case of a 62 year old patient with a personal and family history of many previous thrombotic episodes, both arterial and venous, in whom factor VIII hyperactivity was discovered after a myocardial infarction. This case underlines the association of the factor VIII complex with thrombosis, and its clinical repercussions, especially the incidence of coronary pathology.
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