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  • Title: A putative precursor of isomalabaricane triterpenoids from lanosterol synthase mutants.
    Author: Lodeiro S, Wilson WK, Shan H, Matsuda SP.
    Journal: Org Lett; 2006 Feb 02; 8(3):439-42. PubMed ID: 16435854.
    Abstract:
    [reaction: see text]. Known lanosterol synthase mutants produce monocyclic or tetracyclic byproducts from oxidosqualene. We describe Erg7 Tyr510 mutants that cause partial substrate misfolding and generate a tricyclic byproduct. This novel triterpene, (13alphaH)-isomalabarica-14(27),17E,21-trien-3beta-ol, is the likely biosynthetic precursor of isomalabaricane triterpenoids in sponges. The results suggest the facile evolution of protective triterpenoids in sessile animals.
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