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  • Title: Pulsatile delivery of clarithromycin alone or in combination with amoxicillin against Streptococcus pneumoniae.
    Author: Leuthner KD, Cheung CM, Rybak MJ.
    Journal: Antimicrob Agents Chemother; 2006 Feb; 50(2):813-6. PubMed ID: 16436754.
    Abstract:
    We evaluated pulsatile dosing of clarithromycin and amoxicillin alone or combined against Streptococcus pneumoniae with various susceptibilities. When combined, pulsatile amoxicillin with clarithromycin was superior to either 8- or 12-h dosing against the intermediate strain and was identical for the susceptible strain. Pulse dosing of antimicrobials warrants further investigation.
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