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  • Title: Effect of hypercapnia and hypocapnia on tryptophan and tyrosine hydroxylation in rat brain.
    Author: Carlsson A, Holmin T, Lindqvist M, Siesjö BK.
    Journal: Acta Physiol Scand; 1977 Apr; 99(4):503-9. PubMed ID: 16438.
    Abstract:
    The effects of induced hypo- and hypercapnia upon the rate of hydroxylation of tryptophan and tyrosine in the rat brain were studied by measuring the accumulation of 5-HTP and DOPA following administration of the aromatic L-aminoacid decarboxylase inhibitor 3-hydroxybenzylhydrazine HCl (NSD 1015). The results suggest that the hydroxylation of tryptophan varies directly with the tissue Po2. On the other hand, the hydroxylation of tyrosine did not show a simple relationship to Po2 but appeared to be influenced by pH changes.
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