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  • Title: Synthesis and biological activity of 4'-thio-L-xylofuranosyl purine nucleosides.
    Author: Tiwari KN, Messini L, Montgomery JA, Secrist JA.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2005; 24(10-12):1895-906. PubMed ID: 16438056.
    Abstract:
    A series of some new 4'-thio-L-xylofuranosyl nucleosides were prepared and evaluated as potential anticancer agents. A versatile sugar intermediate for direct coupling with the purine moiety is also synthesized by an efficient and high-yielding route. Proof of structure and configuration at all chiral centers of the nucleosides was obtained by proton NMR. All target compounds were evaluated in a series of human cancer cell lines in vitro. The details of the synthesis of the carbohydrate precursor 1-O-acetyl-2,3,5-tri-O-benzyl-4-thio-L-xylofuranose (6) and corresponding purine nucleosides are presented in the manuscript.
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