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  • Title: The first reported cases of disseminated histoplasmosis in Cambodia, complicated by multiple opportunistic infections.
    Author: Bun Navy K, Prem Prey S, Lynen L, Sovanna P, Bell JD, Harwell JI.
    Journal: Southeast Asian J Trop Med Public Health; 2005 Sep; 36(5):1272-4. PubMed ID: 16438157.
    Abstract:
    Although disseminated histoplasmosis is recognized as a common opportunistic infection in HIV-infected persons living in endemic areas, it is not widely reported in Southeast Asia, and has not been reported in Cambodia. It remains unanswered whether this is secondary to a low disease prevalence, or whether the disease, which is associated with a nonspecific clinical presentation, is under diagnosed. In addition to a review of the literature regarding histoplasmosis in Southeast Asia, we provide a description of two HIV-1 infected patients with documented disseminated histoplasmosis complicating other opportunistic infections in Phnom Penh, Cambodia. These two cases highlight the need for both a high clinical suspicion, and reliable laboratory testing, in a setting where there is likely to be more than one infection complicating the patient's clinical course.
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