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  • Title: Basic fibroblast growth factor treatment for skin ulcerations in scleroderma.
    Author: Yamanaka K, Inaba T, Nomura E, Hurwitz D, Jones DA, Hakamada A, Isoda K, Kupper TS, Mizutani H.
    Journal: Cutis; 2005 Dec; 76(6):373-6. PubMed ID: 16438426.
    Abstract:
    We report the use of topical application of recombinant human basic fibroblast growth factor (rhbFGF) to successfully treat therapy-resistant, chronic leg ulcers in scleroderma. Endothelial cell FGF receptors are directly stimulated by bFGF; also, bFGF promotes the regeneration of capillary-rich granulation tissue. We conclude that topical bFGF may be a powerful new pharmacologic tool for treating severe skin ulcers.
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