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  • Title: Plane-wave fluorescence tomography with adaptive finite elements.
    Author: Joshi A, Bangerth W, Hwang K, Rasmussen J, Sevick-Muraca EM.
    Journal: Opt Lett; 2006 Jan 15; 31(2):193-5. PubMed ID: 16441027.
    Abstract:
    We present three-dimensional fluorescence yield tomography of a tissue phantom in a noncontact reflectance imaging setup. The method employs planar illumination with modulated light and frequency domain fluorescence measurements made on the illumination plane. An adaptive finite-element algorithm is used to handle the ill-posed and computationally demanding inverse image reconstruction problem. Tomographic images of fluorescent targets buried at 1-2 cm depths from the illumination surface demonstrate the feasibility of fluorescence tomography from reflectance tomography in clinically relevant tissue volumes.
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