These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Methanolysis products of disorazole A1.
    Author: Hearn BR, Arslanian RL, Fu H, Liu F, Gramajo H, Myles DC.
    Journal: J Nat Prod; 2006 Jan; 69(1):148-50. PubMed ID: 16441089.
    Abstract:
    Two new disorazole analogues were synthesized by acid-promoted methanolysis of disorazole A1 (1). Structural elucidation of both products (2 and 3), through 1D and 2D NMR experiments, verified that each resulted from epoxide cleavage. With antiproliferative activities in susceptible cell lines comparable to that of disorazole A1, these methanolysis products indicate that the C-9-C-10 epoxide is not an essential structural component for biological activity.
    [Abstract] [Full Text] [Related] [New Search]