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  • Title: HLA-A, -B, and -DRB1 polymorphism defined by sequence-based typing of the Han population in Northern China.
    Author: Yang G, Deng YJ, Hu SN, Wu DY, Li SB, Zhu J, Zhu BF, Liu Y.
    Journal: Tissue Antigens; 2006 Feb; 67(2):146-52. PubMed ID: 16441486.
    Abstract:
    DNA typing for human leukocyte antigen (HLA)-A, -B and -DRB1 was performed using polymerase chain reaction-sequence-based typing method on 618 randomly selected healthy individuals of the Han population in Northern China. Allele frequencies and haplotypes were statistically analyzed. A total of 84 HLA-A alleles, 143 B alleles, and 122 DRB1 alleles were detected, and 853 A-B-DRB1 haplotypes, 473 A-B haplotypes, and 551 B-DRB1 haplotypes were statistically inferred. Statistical analysis of three-locus haplotypes showed that A*0207-B*4601-DRB1*0901 (3.06%) was the most predominant. Gene frequencies and haplotypic associations within HLA-A, -B, and -DRB1 loci were determined at a high-resolution (four digit) allelic level and should provide useful information in anthropology, bone marrow donor registry, legal medicine, and disease association studies.
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