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Title: How cyclodextrins can mask their toxic effect on the blood-brain barrier. Author: Binkowski-Machut C, Hapiot F, Martin P, Cecchelli R, Monflier E. Journal: Bioorg Med Chem Lett; 2006 Apr 01; 16(7):1784-7. PubMed ID: 16442287. Abstract: The toxicity of monosubstituted n-alkyldimethylammonium-beta-cyclodextrins (DMA-C(n)-CD with n=2, 4 and 12) towards endothelial cells of an in vitro model of the blood-brain barrier (BBB) was evaluated and compared to that of the native beta-CD. DMA-C(12)-CD was found to be non-toxic below 10mM due to the self-inclusion of the alkyl chain in the CD cavity. A high percentage of passage (30%) of DMA-C(12)-CD through the endothelial cells has been measured.[Abstract] [Full Text] [Related] [New Search]