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  • Title: Dehydroepiandrosterone sulfate (DHEAS) and risk for mortality among older Taiwanese.
    Author: Glei DA, Goldman N.
    Journal: Ann Epidemiol; 2006 Jul; 16(7):510-5. PubMed ID: 16443373.
    Abstract:
    PURPOSE: Studies based on Western populations showed a negative relationship between dehydroepiandrosterone sulfate (DHEAS) level and mortality, but no study examined this relationship in a non-Western country. We use data from a large, nationally representative sample (n = 963) of older Taiwanese to investigate whether serum DHEAS, predicts subsequent mortality during a 3-year period (2000 to 2003) and whether an effect remains after controlling for baseline health status. METHODS: Baseline data collection included an individual interview, physical examination, and blood sample. A logit model is used to test the relationship between DHEAS level and risk for mortality, controlling for age, sex, and smoking status. RESULTS: Results show a marginally significant inverse relationship between DHEAS level and 3-year mortality risk. Participants with low DHEAS levels (<54.5 microg/dL) have 64% greater odds of dying than those with higher DHEAS levels (p < 0.06). After adjusting for various indicators of health status in 2000, the odds ratio (OR) for low DHEAS level remains substantial (OR = 1.41), but not statistically significant. CONCLUSIONS: Although the analysis is limited by the short follow-up and small number of deaths, results are consistent with the notion that DHEAS level has a sizeable effect on mortality.
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