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  • Title: The ups and downs of BDNF in Rett syndrome.
    Author: Sun YE, Wu H.
    Journal: Neuron; 2006 Feb 02; 49(3):321-3. PubMed ID: 16446133.
    Abstract:
    Rett syndrome (RTT) is an X-linked postnatal neurodevelopmental disorder, which is primarily caused by mutations in the gene encoding methyl-CpG binding protein 2 (MeCP2). A number of MeCP2 target genes have been identified, including the neurotrophic factor BDNF; however, the functional relevance of these targets has not been established. In this issue of Neuron, Chang et al. provide the first in vivo evidence for a functional interaction between BDNF and MeCP2.
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