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  • Title: [Association between genetic polymorphisms in methylentetrahydrofolate reductase and risk of lung cancer].
    Author: Zhang XM, Miao XP, Tan W, Qu SN, Sun T, Zhou YF, Lin DX.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2005 Dec; 27(6):700-3. PubMed ID: 16447641.
    Abstract:
    OBJECTIVE: To investigate the association between methylentetrahydrofolate reductase (MTHFR) polymorphisms and risk of lung cancer. METHODS: Totally 505 cases with lung cancer and 500 frequency-matched controls were genotyped for the MTHFR C677T and A1298C polymorphisms by polymerase chain reaction-restriction fragment length polymorphism methods. The odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression model. Haplotype frequency was estimated using EH software. RESULTS: The frequency of the MTHFR C677T allele in cases was significantly higher than that in controls (53.5% vs 44.9%, P < 0.001). Compared with the 677CC genotype, the 677CT and 677TT genotypes were associated with increased risk of lung cancer, with the OR being 1.43 (95% CI, 1.04-1.95) and 2.40 (95% CI, 1.61-3.59), respectively. In addition, a significant difference in the distribution of haplotype frequencies between cases and controls was observed. CONCLUSION: Functional polymorphism in MTHFR is associated with increased risk of lung cancer in Chinese population.
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