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  • Title: Isolation and characterization of 'dense particles' from poliovirus-infected HeLa cells.
    Author: Yamaguchi-Koll U, Wiegers KJ, Drzeniek R.
    Journal: J Gen Virol; 1975 Mar; 26(3):307-19. PubMed ID: 164520.
    Abstract:
    Dense poliovirus particles (buoyant density 1.44 g/ml in CsCl) isolated from infected HeLa cells contain the normal four structural polypeptides VP1 to VP4, and 35S poliovirus RNA. In addition, small amounts of VPo and single-stranded RNA sedimenting slower than the poliovirus genome are present. Dense particles have a low specific infectivity, are neutralized by type-specific poliovirus antisera, and are detected during growth as early as normal virus but disappear when virus production stops. They appear to represent a different, more open, conformation of the normal virus capsid.
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