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  • Title: Effects of Mg2+ and ATP on the phosphate transporter of sarcoplasmic reticulum.
    Author: Stefanova HI, Jane SD, East JM, Lee AG.
    Journal: Biochim Biophys Acta; 1991 May 07; 1064(2):329-34. PubMed ID: 1645201.
    Abstract:
    The extra uptake of Ca2+ by vesicles of sarcoplasmic reticulum (SR) observed in the presence of Pi, attributable to transport of Pi by the Pi-transporter, has been studied. It has been shown that the Pi transporter is stimulated by ATP. Single channel conductance measurements have shown that the Cl- channel in the SR membrane is impermeable to Pi. It is suggested that the transporter could be an ion antiporter system. Studies of uptake as a function of pH and Mg2+ concentration suggest that transport of MgHPO4 and H2PO-4 are faster than transport of HPO2-4. For oxalate and pyrophosphate, Mg2+ binding inhibits transport. It is suggested that protonation of lysine residue(s) at the anion binding site increase the rate of transport.
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