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  • Title: Massive creatine kinase elevations with quetiapine: report of two cases.
    Author: Klein JP, Fiedler U, Appel H, Quante A, Jockers-Scherübl MC.
    Journal: Pharmacopsychiatry; 2006 Jan; 39(1):39-40. PubMed ID: 16453254.
    Abstract:
    Massive elevations of serum creatine kinase (CK) can occur in a significant number of patients treated with neuroleptics in the absence of neuroleptic malignant syndrome (NMS). We report two cases of CK-elevations associated with quetiapine treatment, which disappeared after drug discontinuation. To our knowledge, case number one is the first case of quetiapine-induced CK elevation in a neuroleptic-naïve patient. We thus suggest CK assessment when myalgia occurs with neuroleptic treatment.
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