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  • Title: [Fever and hyperprolactinaemia as the onset of Langerhans cell histiocytosis].
    Author: Artigues Barceló A, Guiscafré Fontirroig P, de Miguel Sebastián P, Salgado RM, Albiol Varella MT.
    Journal: An Med Interna; 2005 Nov; 22(11):535-7. PubMed ID: 16454588.
    Abstract:
    Langerhan's cell histiocytosis (LCH) is a rare disorder in which granulomatous deposits occur at multiple sites within the body. The aetiology is unknown. Is more frequent in children. Presenting symptoms are polyuria and polydipsia, due to diabetes insipidus, other symptoms are skin rash, dyspnea and tachypnea. Diagnosis is reached by biopsy of lesions, in which Langerhan's cell are found. Prognosis is variable, depending the site affected; therefore, treatment must be individually. The hyperprolactinaemia in LCH is very rare and its related with anterior pituitary deficiency. There are not many cases described, all of them during the course of the disease, not as the onset. We describe a 22 year-old woman with Langerhan's cell histiocytosis which initial presentation was fever and hyperprolactinaemia.
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