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  • Title: [Congenital Wilms' tumors are mostly (benign) mesoblastic nephromas--significance of prenatally detected solid kidney tumors].
    Author: Gutjahr P.
    Journal: Geburtshilfe Frauenheilkd; 1991 Feb; 51(2):124-6. PubMed ID: 1645691.
    Abstract:
    In a nationwide study (1980-1988) for the diagnosis and treatment of Wilms' tumours (nephroblastomas), which are highly malignant embryonal mixed tumours of the kidney and show distant metastases at the time of diagnosis in 10-20% of cases, 78% of 373 children had a standard type Wilms' tumour, 7% had benign variants and 14% had high grade malignancy variants of the classical type. 20 of the 25 benign variants occurred in infants. From the 25, 16 tumours were congenital mesoblastic nephromas, 14 of which occurred in infants. As the detection of a solid renal tumour mass in the prenatal sonogram (showing an echotexture resembling that of the liver) may suggest Wilms' tumour, we analysed 11 neonates (1-14 days old), in which Wilms' tumours had been diagnosed (n = 11; 2.9%) for the histological subtype. In 9 of the 10 neonates, the final diagnosis was congenital mesoblastic nephroma. These congenital mesoblastic nephromas are cured by surgery alone. Thus, if a solid renal tumour suspected as a Wilms' tumour, is prenatally detected, the most probable diagnosis is that of the benign variant congenital mesoblastic nephroma, and, in this case, preterm delivery (e.g. to prevent metastasising and to start treatment as early as possible) is not indicated.
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