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  • Title: Influence of angiotensin II on the alpha-adrenoceptors involved in mediating the response to sympathetic nerve stimulation in the rabbit isolated distal saphenous artery.
    Author: Dunn WR, McGrath JC, Wilson VG.
    Journal: Br J Pharmacol; 1991 Jan; 102(1):10-2. PubMed ID: 1646053.
    Abstract:
    Under normal experimental conditions, sympathetic nerve-mediated responses to electrical field stimulation in the isolated distal saphenous artery of the rabbit are sensitive to prazosin (0.1 microM) and so, by definition, are mediated by alpha 1-adrenoceptors. In the presence of angiotensin II (A II, 0.05 microM) however, a component of the response to nerve stimulation became resistant to prazosin. This 'uncovered' response was virtually abolished by the selective alpha 2-adrenoceptor antagonist rauwolscine (1 microM), a concentration that in the absence of A II had enhanced nerve-mediated responses. Exposure to A II therefore, allows the clear demonstration of a role for postjunctional alpha 2-adrenoceptors in mediating the contractile response to sympathetic nerve stimulation in this arterial preparation.
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