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  • Title: Monitoring of vancomycin serum levels for the treatment of staphylococcal infections.
    Author: Kitzis MD, Goldstein FW.
    Journal: Clin Microbiol Infect; 2006 Jan; 12(1):92-5. PubMed ID: 16460555.
    Abstract:
    Vancomycin serum concentrations were determined for 1,737 patients treated with either 2 x 1 g of vancomycin or 4 x 500 mg daily (780 patients), according to current nomograms, or by continuous infusion (957 patients) with a loading dose (1 g) and a total of 2-6 g daily. Trough serum concentrations were determined after 36-48 h. Adequate serum levels for the treatment of a normal methicillin-resistant Staphylococcus aureus (MRSA) and a glycopeptide-intermediate S. aureus (GISA) were observed in 81% and 20.9% of patients, respectively. The data support theoretical arguments that higher and more sustained serum levels of vancomycin, obtained by continuous infusion, may enhance clinical efficacy.
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