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  • Title: Proton, calcium, and magnesium binding by peptides containing gamma-carboxyglutamic acid.
    Author: Cabaniss SE, Pugh KC, Pedersen LG, Hiskey RG.
    Journal: Int J Pept Protein Res; 1991 Jan; 37(1):33-8. PubMed ID: 1646183.
    Abstract:
    gamma-Carboxyglutamic acid (Gla) is believed to bind Ca [II] ions and Mg [II] ions in prothrombin and other coagulation proteins. Binding constants for H+, Ca [II] ions, and Mg [II] ions to Gla-containing peptides are determined using pH and ion selective electrode titrations. The binding constants for peptides containing a single Gla residue are similar to the constants for malonic acid. Peptides containing two Gla residues in sequence (di-Gla peptides) bind Ca [II] ions and Mg [II] ions more strongly. KMgL for the di-Gla peptides is similar to the site-binding constant for Ca [II] ions in denatured BF1. These di-Gla peptides may be useful analogs for metal binding by the disordered Gla domain in BF1.
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