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  • Title: Rosai-Dorfman disease: two case reports and diagnostic role of fine-needle aspiration cytology.
    Author: Ruggiero A, Attinà G, Maurizi P, Mulè A, Tarquini E, Barone G, Lazzareschi I, Riccardi R.
    Journal: J Pediatr Hematol Oncol; 2006 Feb; 28(2):103-6. PubMed ID: 16462585.
    Abstract:
    Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy (SHML), is a rare and self-limiting benign disorder that most commonly involves the cervical lymph nodes. The authors describe two cases of SHML. Fine-needle aspiration of the lymphadenopathy was performed in both patients. Immunocytochemical and histologic features, as the evidence of emperipolesis and S100 protein positivity on immunostaining, were typical of SHML. Fine-needle aspiration cytology plays an important diagnostic role in SHML and may be conclusive in a typical clinical setting. The diagnosis of SHML should be considered in the differential diagnosis of massive, painless cervical lymphadenopathy. Long-term follow-up is necessary to observe the complete regression of the massive lymphadenopathy. However, specific therapy is available and should be limited to patients with compressive symptoms or extranodal disease.
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