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  • Title: Gastrointestinal stromal tumour presenting with severe bleeding: a review of the molecular biology.
    Author: Towu E, Stanton M.
    Journal: Pediatr Surg Int; 2006 May; 22(5):462-4. PubMed ID: 16463034.
    Abstract:
    Gastrointestinal stromal tumours (GIST) are rare in children. A 7-year-old boy presented acutely with a severe upper gastrointestinal bleed and was found following angiography to have such a tumour in the duodenum, which was resected at laparotomy. The presence of CD 117 positive immunostaining was a confirmatory diagnostic marker. The prognosis and underlying molecular biology of the tumour is discussed. Understanding of the molecular pathogenesis has given rise to promising new therapies.
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