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  • Title: Subdural intracranial pressure, cerebral perfusion pressure, and degree of cerebral swelling in supra- and infratentorial space-occupying lesions in children.
    Author: Stilling M, Karatasi E, Rasmussen M, Tankisi A, Juul N, Cold GE.
    Journal: Acta Neurochir Suppl; 2005; 95():133-6. PubMed ID: 16463837.
    Abstract:
    UNLABELLED: To our knowledge comparative studies of intracranial pressure (ICP) and degree of cerebral swelling during craniotomy for supratentorial or infratentorial space occupying lesion in children are not available. In this prospective study subdural ICP, cerebral perfusion pressure (CPP), dural tension, and the degree of cerebral swelling were analysed in supine and prone positioned children subjected to craniotomy for space occupying lesions. MATERIAL AND METHOD: 48 children with space occupying tumours were subjected to either isoflurane/nitrous oxide 50%/fentanyl (n = 22) or propofol/fentanyl/air/oxygen (n = 26). 25 children were operated supratentorially in supine position, while 23 patients were operated infratentorially in the prone position. Subdural ICP, mean arterial blood pressure (MABP), and CPP were measured just before opening of the dura. Dural tension was estimated before opening of dura, and the degree of cerebral swelling was estimated after opening of dura. RESULTS: The age and weight of children anaesthetised with isoflurane in the prone position were significantly lower than the propofol anaesthetised groups. No significant inter-group differences as regards tumour size, midline shift, rectal temperature, MABP or PaCO2 were found. ICP in prone positioned children averaged 16.9 mm Hg against 9.0 mm Hg in supine positioned children (p < 0.001). In prone positioned children the dura was significantly tenser, and the degree of brain swelling after opening of dura was significantly more pronounced. No significant difference as regard ICP was disclosed when isoflurane/nitrous oxide/fentanyl and propofol/ fentanyl anaesthetized children were compared, but MABP and CPP were significantly lower in isoflurane anaesthetised children. CONCLUSION: In children with cerebral tumours ICP is higher, and the degree of cerebral swelling more pronounced in the prone-compared with supine positioned children. Choice of anaesthesia did not influence ICP, but CPP was significantly lower during isoflurane anaesthesia.
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