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  • Title: The effect of polycarbophil gel (Replens) on bacterial vaginosis: a pilot study.
    Author: Wu JP, Fielding SL, Fiscella K.
    Journal: Eur J Obstet Gynecol Reprod Biol; 2007 Jan; 130(1):132-6. PubMed ID: 16464528.
    Abstract:
    OBJECTIVE: To determine if use of intravaginal polycarbophil gel (Replens) for 1 month will: (1) lower vaginal pH; (2) improve signs of bacterial vaginosis (BV). STUDY DESIGN: Seventeen women with BV self-administered polycarbophil gel every third day for 4 weeks in an open-label, prospective pilot study. Primary outcome measures included vaginal pH, presence of amines and Nugent scores. RESULTS: At week 4, there was improvement in Nugent scores, vaginal odor and clue cell count (p<0.05). Eleven women converted from amine positive to negative (73+/-20%). There was no significant change in vaginal pH. CONCLUSIONS: Polycarbophil gel is associated with improved signs of BV, although not vaginal pH.
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