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  • Title: Substituted coumarins as potent 5-lipoxygenase inhibitors.
    Author: Grimm EL, Brideau C, Chauret N, Chan CC, Delorme D, Ducharme Y, Ethier D, Falgueyret JP, Friesen RW, Guay J, Hamel P, Riendeau D, Soucy-Breau C, Tagari P, Girard Y.
    Journal: Bioorg Med Chem Lett; 2006 May 01; 16(9):2528-31. PubMed ID: 16464579.
    Abstract:
    Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure-activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme.
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