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  • Title: Development of a competitor DNA template of the 38 kDa gene for molecular quantification of M. tuberculosis.
    Author: Dwivedi A, Sehajpal PK.
    Journal: Int J Tuberc Lung Dis; 2005 Dec; 9(12):1412-4. PubMed ID: 16466067.
    Abstract:
    The molecular quantification of Mycobacterium tuberculosis (TB) from clinical samples can improve the management of TB. Competitive polymerase chain reaction (C-PCR) is an accepted technique often used for this purpose, and IS6110 is the most popular target in such studies. As the number of these elements varies from 0 to 16 in clinical isolates, it is prone to give inconsistent results. A simple PCR-based approach is described in this study to generate a novel competitor for a single copy 38 kDa gene for the development of C-PCR for the quantification of the M. tuberculosis genome.
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