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  • Title: ESR measurement of radical clearance in lung of whole mouse.
    Author: Takeshita K, Utsumi H, Hamada A.
    Journal: Biochem Biophys Res Commun; 1991 Jun 14; 177(2):874-80. PubMed ID: 1646612.
    Abstract:
    Clearance of the nitroxide radicals, hydroxy-TEMPO and carboxy-PROXYL, in whole-mouse lung was directly measured by in vivo ESR. After injecting a nitroxide radical, distribution of the nitroxide radical all over the lung was confirmed by ESR imaging. The ESR signal of hydroxy-TEMPO was reduced in the lung and the clearance obeyed first-order kinetics, whereas the signal of carboxy-PROXYL remained constant. Comparison of the clearance rates of live and dead mice indicated the presence of 2 different clearance systems in the lung: loss of its paramagnetism in the lung, and transfer from alveolar to the blood circulation system.
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