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  • Title: Antibiotics which target the Wolbachia endosymbionts of filarial parasites: a new strategy for control of filariasis and amelioration of pathology.
    Author: Pfarr KM, Hoerauf AM.
    Journal: Mini Rev Med Chem; 2006 Feb; 6(2):203-10. PubMed ID: 16472187.
    Abstract:
    Wolbachia endosymbionts of filariae are targets for the development of new antifilarial chemotherapy. Doxycycline to deplete Wolbachia from the worm has demonstrated the feasibility of this strategy and has provided a new chemotherapeutic tool. Recent research shows that depleting Wolbachia will also lessen pathology, and lessen adverse reactions to traditional antifilarial drugs.
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