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  • Title: Platelet [3H]-imipramine binding and leukoencephalopathy in geriatric depression.
    Author: Husain MM, Knight DL, Doraiswamy PM, Figiel GS, McDonald WM, Boyko OB, Krishnan KR, Nemeroff CB.
    Journal: Biol Psychiatry; 1991 Apr 01; 29(7):665-70. PubMed ID: 1647227.
    Abstract:
    We examined the relationship between platelet [3H]-imipramine binding and leukoencephalopathy as assessed by 1.5 Tesla Magnetic Resonance Imaging (MRI) in 21 elderly depressed patients who satisfied DSM-III criteria for major depression. Both drug-free platelet [3H]-imipramine binding and brain MRI studies were obtained during the same episode of depression. Our findings show a significant inverse relationship between frequency of subcortical hyperintensity (SCH) and the number (Bmax) of platelet [3H]-imipramine binding sites. Patients with Bmax less than 850 fmol/mg protein had significantly larger SCH compared with patients with a higher Bmax. These data provide further support to the potential use of platelet [3H]-imipramine binding studies and brain MR imaging as diagnostic adjuncts in geriatric depression and suggest, moreover, that these two biological markers may be linked in geriatric patients with depression.
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