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  • Title: Axonal neuropathy in a patient with monoclonal IgM kappa reactive with Schmidt-Lantermann incisures.
    Author: Quattrini A, Nemni R, Fazio R, Iannaccone S, Lorenzetti I, Grassi F, Canal N.
    Journal: J Neuroimmunol; 1991 Jul; 33(1):73-9. PubMed ID: 1647411.
    Abstract:
    We report a patient with a progressive, predominantly sensory neuropathy and a IgM kappa M-protein that binds to Schmidt-Lantermann incisures. A sural nerve biopsy showed primary axonal damage and IgM deposits at Schmidt-Lantermann incisures were seen by direct immunoperoxidase. Serum from the patient injected into rat sciatic nerve reacts with the incisures as with those in the patient's nerve. The IgM kappa M-protein reacts with chondroitin sulfate C and binds to a broad nerve protein band with a mobility of between 170 and 118 kDa. Peripheral neuropathy may be related to the M-protein, which had immunocytochemical reactivity not previously described for patients with polyneuropathy and IgM monoclonal gammopathy.
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