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  • Title: Autoimmunity to lysosomal enzymes: new clues to vasculitis and glomerulonephritis?
    Author: Kallenberg CG, Tervaert JW, van der Woude FJ, Goldschmeding R, von dem Borne AE, Weening JJ.
    Journal: Immunol Today; 1991 Feb; 12(2):61-4. PubMed ID: 1647776.
    Abstract:
    The demonstration of autoantibodies to neutrophil cytoplasmic antigens (ANCA) in (1) systemic vasculitides such as Wegener's granulomatosis, classic polyarteritis nodosa and the Churg Strauss syndrome and (2) idiopathic crescentic glomerulonephritis has placed these disorders within the spectrum of autoimmune diseases. The target antigens have been identified as myeloid lysosomal enzymes that are involved in tissue destruction by neutrophils. Recent data suggest a pathogenetic role for these autoimmune responses. The autoantibodies may activate neutrophils, resulting in extensive tissue necrosis. Alternatively, T-cell-mediated immunity to these positively-charged enzymes that localize to polyanionic basement membranes may, in concert with the presence of autoantibodies, result in glomerulonephritis and vasculitis.
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