These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Tris(pyrone) chelates of Gd(III) as high solubility MRI-CA.
    Author: Puerta DT, Botta M, Jocher CJ, Werner EJ, Avedano S, Raymond KN, Cohen SM.
    Journal: J Am Chem Soc; 2006 Feb 22; 128(7):2222-3. PubMed ID: 16478170.
    Abstract:
    Two tripodal, hexadentate pyrone-based chelators have been prepared. These ligands form stable, soluble complexes with gadolinium(III). The complexes show aqueous stability comparable to that of [Gd(DTPA)]2- at pH 7.4. Evaluation by relaxometry shows that these complexes have two inner-sphere water molecules and a very fast water exchange rate. The solution behavior of these complexes suggests that they may be attractive as high relaxivity, next-generation magnetic resonance imaging contrast agents.
    [Abstract] [Full Text] [Related] [New Search]