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  • Title: [Factors and mechanisms involved in the transmission and development of congenital infection with Trypanosoma cruzi].
    Author: Carlier Y.
    Journal: Rev Soc Bras Med Trop; 2005; 38 Suppl 2():105-7. PubMed ID: 16482827.
    Abstract:
    This paper synthesizes the results obtained from multidisciplinary studies of Bolivian cases of congenital infection with T. cruzi. Congenital infection and congenital Chagas disease do not result from transmission of a particular strain of parasite, but from an equilibrium between complex phenomena, such as a weak maternal type 1 adaptative immune response associated with high maternal parasitemia, an invasion of placental chorion and umbilical cord by parasites, in front of a fetal T. cruzi-specific immune response characterized by an activation of cytotoxic CD8 T cells producing IFN-gamma and able to limit parasite multiplication and morbi-mortality of congenital Chagas disease.
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